Venus Williams struggled past Kimiko Date-Krumm, the 40 year old Japanese player was desperately unlucky to lose out on centre court. Five time champion Williams started the tournament as third favourite but has now dropped behind Petra Kvitova (8/1, Sportingbet) in the betting at 19/2 with Betfair.

Elsewhere there was a welcome win for Brit Laura Robson who played some emphatic forehands to come from a set down to progress, she remains a long shot at a massive 1999/1 with unibet as she will meet 4/1 favourite Maria Sharapova in the next round.

In the mens draw, Nadal, Roddick and Murray made it through to the third round in convincing straight set wins but Del Potro fell a set behind in his match with Belgian Olivier Rochus. The Argentine was fifth favourite before the tournament kicked off but went down in the tiebreak before the match was suspended for the day. He remains strong a good bet to progress though at 1/3 with Bet365.

Here are a few others to look out for on day four.

Robin Soderling v Leyton Hewitt (Soderling to win at 4/11 with Blue Sq)

The opener on centre court should not daunt either player, but Soderling should be much stronger. Hewitt has lost the zip which led him to the title in 2002 and is carrying a foot injury. He managed to get through his first round with Nishikori which was somewhat of a surprise but the inexperience of the Japanese star is no match for Soderling.

The Swede is a commanding figure on court at 6 ft 4 and at 5th in the world is a whole 125 places above Hewitt in the ATP rankings. Only! Djokovi c, Nadal and Del Potro have got the better of Soderling in the last five tournaments and it is highly unlikely Hewitt will add to that list.

John Isner v Nicolas Almagro (Isner to win at 1/2 with Sportingbet)

Isner made sure there was no repeat of the longest match in tennis history with a much quicker straight set win over Mahut in the first round and with his huge serve will expect another victory over clay court specialist Almagro.

The Spaniard is uncomfortable on grass and lost his only previous match on the surface this year to Berrer and has exited Wimbledon at the first round on three out of
five occasions. In the unchartered territory of the second big serving, 6 ft 9 Isner will be a challenge too big.

Maria Kirilenko v Tamarine Tanasugarn (Kirilenko to win at 5/6 with Skybet)

Both came through their first round matches in straight sets but Kirilenko looks the better to progress to the next stage. Previous to her first round win over 123rd ranked Yaroslave Shvetova, Tanasugarn had lost in the first round in straight sets in her last two Wimbledon appearances.

Kirilenko is in good form, the Russian narrowly missed out on a quarter final at Roland Garros in a three-setter with Andrea Petkovic and her current ranking at 27th in the world shows her superiority. A 2-0 set win for Kirilenko may well be on the cards and the odds are good at 15/8 with Skybet.